Design principles of engineered immune systems
Cancer Immunotherapy has dramatically revitalized immuno-oncology, but many challenges still remain. We develop and leverage CRISPR-based platforms in primary human T cells to discover ways to engineer robust anti-tumor immunity.
Our goal is to design breakthrough cell-based therapies and learn how to engineer immune cells to function in the suppressive tumor microenvironment.
Latest: Discovering regulators of human T cell proliferation using Genome-wide CRISPR screens - published in Cell